2. Signaling Pathways
  3. GPCR/G Protein
  4. Vasopressin Receptor
  5. V2 Receptor  Isoform
  6. V2 Receptor  Inhibitor

V2 Receptor  Inhibitor

V2 Receptor  Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-109133
    Pecavaptan
    		Inhibitor
    Pecavaptan is an orally active and dual antagonist of V1a/V2 receptor (Ki=0.5 nM and 0.6 nM for human, respectively). Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema.
  • HY-165423
    DM-4111
    		Inhibitor
    DM-4111, one of the major monohydroxyl metabolites of Tolvaptan (HY-17000), is a potent vasopressin V2 receptor inhibitor. DM-4111 inhibits water reabsorption in the renal tubules, thereby promoting the excretion of electrolyte-free water. DM-4111 is promising for research of cardiovascular diseases.